MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo
نویسندگان
چکیده
MyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3-positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.
منابع مشابه
Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 175 شماره
صفحات -
تاریخ انتشار 2006